The R282Q evidence conflict
A TP53 missense variant with a deposited mutant structure, mixed functional observations, and current ClinVar disagreement.
- Protein
- NP_000537.3:p.Arg282Gln
- Condition
- Li-Fraumeni syndrome 1
Put a genetic variant on trial.
GeneCourt turns a real variant-evidence conflict into a transparent, replayable hearing. Every claim stays attached to a public source; every caveat remains on the record.
Question before the court
Verified teaching docket
Hear the disagreement first, then use the expert-reviewed control to calibrate what a clearer record looks like.
A TP53 missense variant with a deposited mutant structure, mixed functional observations, and current ClinVar disagreement.
A TP53 missense variant with an expert-panel ClinVar classification and convergent functional evidence.
The court's rules
Public records and papers are captured with identifiers, dates, and exact spans.
Variant, condition, model, and method scope are examined before an item is admitted.
The final case file separates established, disputed, contextual, and missing evidence.